Huang, Xi-Shou published the artcileThe synthesis, structure and activity evaluation of secnidazole derivatives as Helicobacter pylori urease inhibitors, Application In Synthesis of 328-90-5, the publication is Current Bioactive Compounds (2011), 7(4), 268-280, database is CAplus.
Various secnidazole derivatives were synthesized and evaluated for Helicobacter pylori (H. pylori) urease inhibitory activities and anti-inflammatory activities. The most potent urease inhibitory activities and anti-inflammatory activities were in the range of IC50 = 1.0-2.0 μM and 59-72% inhibition, resp. Docking simulation was performed with one of the compounds into the urease active site to determine the probable binding model. The compounds with potent inhibitory activity against H. pylori may be potential antibacterial agents.
Current Bioactive Compounds published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.
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