Zhang, Qifeng published the artcileSulfur(IV)-mediated umpolung α-heterofunctionalization of 2-oxazolines, Product Details of C8H10S, the publication is Chemical Science (2022), 13(18), 5164-5170, database is CAplus and MEDLINE.
The α-umpolung of carbonyl compounds significantly expands the boundaries of traditional carbonyl chem. Despite various umpolung methods available today, reversing the inherent reactivity ofcarbonyls still remains a substantial challenge. In this article, the authors report the first use of sulfonium salts, in lieu of well-established hypervalent iodines, for the carbonyl umpolung event. The protocol enables the incorporation of a wide variety of heteroatom nucleophiles into the α-carbon of 2-oxazolines. The success of this investigation hinges on the following factors: (1) the use of sulfoxides, which are abundant, structurally diverse and tunable, and easily accessible, ensures the identification of a superior oxidant namely phenoxathiin sulfoxide for the umpolung reaction; (2) the “assembly/deprotonation” protocol previously developed for rearrangement reactions in the authors’ laboratory was successfully applied here for the construction of α-umpoled 2-oxazolines.
Chemical Science published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C7H16ClNO2, Product Details of C8H10S.
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