623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
4-aminobenzyl alcohol (1 g, 8.12 mmol) was dissolved in 5 mL of 5M hydrochloric acid solution,A solution of sodium nitrite (840 mg, 12.18 mmol, dissolved in 20 mL of deionized water) was added dropwise to the solution. The mixture was added dropwise within 30 minutes. The reaction mixture was vigorously stirred in an ice-water bath.Sodium azide (2.1 g, 32.3 mmol) was added portionwise to the reaction system, and the resulting mixture was stirred at room temperature overnight. After the reaction is complete,The residue was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The organic layer was washed with saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated.The crude product was isolated and purified by silica gel column chromatography (EA:PE=1:3, volume ratio) to give 950 mg of a yellow oily liquid in a yield of 78.0%.
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Reference:
Patent; Peking University; Tang Xinjing; Jin Qingqing; (36 pag.)CN107365254; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts