6338-55-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of SL_0160 (269 mg, 732 mumol) in MeCN (10 mL) was added 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (109 mg, 732 mumol) followed by NEt3 (200 muL, 145 mumol). The resulting yellow solution was left at 22 C. for 24 hours, at which point TLC analysis indicated complete consumption of starting material. Solvent was removed in vacuo, and crude residue was purified by silica gel chromatography (0?100% EtOAc/hexanes) to provide 220 mg (80% yield) of SL_0483 as a clear oil. 1H NMR (300 MHz, DMSO-d6) delta 7.15 (t, J=5.4 Hz, 1H), 5.62 (dt, J=11.4, 5.7 Hz, 1H), 5.49 (dt, J=11.4, 6.5 Hz, 1H), 4.57-4.51 (m, 3H), 4.24 (d, J=5.7 Hz, 2H) 3.51-3.46 (m, 6H), 3.42-3.37 (m, 4H), 3.11 (q, J=5.9 Hz, 2H), 0.87 (s, 9H), 0.05 (s, 6H). MS (ESI+) calc’d for C17H35NaNO6Si+ [M+H]+ 400.21, found 400.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Promega Corporation; Levin, Sergiy; Ohana, Rachel Friedman; Kirkland, Thomas; Wood, Keith V.; (117 pag.)US2016/355523; (2016); A1;,
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