Lee, J.-H. published the artcileSecond-phase validation study of an alternative developmental toxicity test using mouse embryonic stem cell-derived embryoid bodies, Related Products of alcohols-buliding-blocks, the main research area is toxicity mouse embryonic stem cell embryoid body.
The embryoid body test (EBT) is a developmental toxicity test method that measures the size of embryoid bodies (EBs) and the viability of mouse embryonic stem cells (mESCs) and fibroblasts (3T3 cells). The previous pre-validation study confirmed the high accuracy (above 80%) of EBT using 26 coded test chems. This second-phase validation study assessed the inter-laboratory reproducibility (5 chems. in common) and predictive capacity (10 chems. in each laboratory) test using the coded test chems. at three laboratories For the prediction model, the accuracy is increased when more data is accumulated. Therefore, we updated the prediction model and analyzed the results of the second year with the newly created-prediction model. Statistical anal. of the inter-laboratory reproducibility test results indicated that accuracy, sensitivity, and specificity were 87%, 78%, and 100%, resp. The results of the statistical anal. of the predictive capacity test showed an accuracy of 80%, sensitivity of 78%, and specificity of 81%. In conclusion, the EBT can accurately classify various embryotoxicants within a short period and with relatively little effort. Therefore, EBT can be used as a good way to test developmental toxicity.
Journal of Physiology and Pharmacology published new progress about Chemicals. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.
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