Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 13826-35-2, Name is (3-Phenoxyphenyl)methanol, molecular formula is C13H12O2. In an article, author is Herle, Bart,once mentioned of 13826-35-2, Category: alcohols-buliding-blocks.
Total Synthesis of Mycinolide IV and Path-Scouting for Aldgamycin N
Proof-of-concept is provided that a large estate of 16-membered macrolide antibiotics can be reached by a unified approach. The key building block was formed on scale by an asymmetric vinylogous Mukaiyama aldol reaction; its alkene terminus was then converted either into the corresponding methyl ketone by Wacker oxidation or into a chain-extended aldehyde by catalyst-controlled branch-selective asymmetric hydroformylation. These transformations ultimately opened access to two structurally distinct series of macrolide targets. Notable late-stage maneuvers comprise a rare example of a ruthenium-catalyzed redox isomerization of an 1,3-enyne-5-ol into a 1,3-diene-5-one derivative, as well as the elaboration of a tertiary propargylic alcohol into an acyloin by trans-hydrostannation/Chan-Lam-type coupling. Moreover, this case study illustrates the underutilized possibility of forging complex macrolactone rings by transesterification under essentially neutral conditions.
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Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts