Wojtunik-Kulesza, Karolina published the artcilePreliminary Studies on the Effect of Simulated Digestion on the Antioxidant Activity of Monoterpenes, HPLC of Formula: 106-25-2, the publication is Chemistry & Biodiversity (2022), 19(4), e202100995, database is CAplus and MEDLINE.
One of several possible ways of predicting substance bioactivity under in vivo conditions is through simulated studies based on conditions comparable to those within the organism. Having regards to pH and digestive enzymes, such an approach is through simulated digestion. Simulated studies allow gaining an understanding of physiol. conditions and a prediction of compound behavior. The presented studies are based on simulated digestion (SD) to which selected monoterpenes (γ-terpinene, α-terpinene, α-phellandrene, carvone, menthone, isopulegol, α-pinene, β-pinene, terpinene-4-ol, linalool, eucalyptol, p-cymene, citral, citronellal) have been subjected. The procedure included changes pH (2.0 and 8.5) and digestive enzymes (pepsine in gastric stage and pancreatin in duodenal stage) to better understand what goes on within the gastro-intestinal tract. The changes were observed for gastric and duodenal stages, as well as for two phases: oil and water. Obtained results revealed both pos. and neg. influence of gastrointestinal conditions on monoterpenes antioxidant activity. However, pos. impact prevailed (γ-terpinene, citral, eucalyptol, isopulegol, α-pinene). The differentiation in activity can be explained by solubility in oil/water phases and the biotransformation of studied compounds
Chemistry & Biodiversity published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C6H10F3NO, HPLC of Formula: 106-25-2.
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