Rapolu, Rajesh Kumar published the artcileShort enantioselective routes to (S)-Dapoxetine, Formula: C19H18O2, the publication is Chemistry & Biology Interface (2013), 3(1), 50-60, database is CAplus.
Two enantioselective approaches involving a stereoselective conjugate addition of a homochiral lithium amide based on (R)-N-(1-phenylethyl)benzylamine and a stereoselective ketone reduction of a prochiral ketone were employed for a chiral synthesis of (S)-dapoxetine. Both routes employ readily and com. viable starting materials and reagents, and suitable for process synthesis of (αS)-N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine (Dapoxetine hydrochloride) (I). The synthesis of the target compound was achieved using 3-chloro-1-phenyl-1-propanone as a starting material.
Chemistry & Biology Interface published new progress about 156453-53-1. 156453-53-1 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Benzene,Naphthalene,Alcohol,Ether, name is (R)-3-(Naphthalen-1-yloxy)-1-phenylpropan-1-ol, and the molecular formula is C19H18O2, Formula: C19H18O2.
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