Barker, Graeme published the artcileChirality Transfer in Gold(I)-Catalysed Direct Allylic Etherifications of Unactivated Alcohols: Experimental and Computational Study, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Chemistry – A European Journal (2015), 21(39), 13748-13757, database is CAplus and MEDLINE.
Gold(I)-catalyzed direct allylic etherifications have been successfully carried out with chirality transfer to yield enantioenriched, γ-substituted secondary allylic ethers. Our investigations include a full substrate-scope screen to ascertain substituent effects on the regioselectivity, stereoselectivity and efficiency of chirality transfer, as well as control experiments to elucidate the mechanistic subtleties of the chirality-transfer process. Crucially, addition of mol. sieves was found to be necessary to ensure efficient and general chirality transfer. Computational studies suggest that the efficiency of chirality transfer is linked to the aggregation of the alc. nucleophile around the reactive π-bound Au-allylic ether complex. With a single alc. nucleophile, a high degree of chirality transfer is predicted. However, if three alcs. are present, alternative proton transfer chain mechanisms that erode the efficiency of chirality transfer become competitive.
Chemistry – A European Journal published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.
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https://en.wikipedia.org/wiki/Alcohol,
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