Zhang, Quan published the artcileCarboalumination-epoxide ring opening for the formation of 1,4-disubstituted (Z)-3,6-alkadienols, Related Products of alcohols-buliding-blocks, the publication is Chinese Journal of Chemistry (2013), 31(6), 773-778, database is CAplus.
Allylalumination of alkynes, i.e. forming Negishi’s (Z)-alkenyl dialkylalane, followed by alkenylation of epoxides provides 1,4-disubstituted (Z)-3,6-alkadienols. The alkenylation can be facilitated by the presence of a neighboring coordinating group in the epoxides. This “one-pot” approach was successfully applied in the large-scale production of the C(10)-C(15) fragment of 9,10-dehydroepothilone D, a synthetic epothilone analog as an anticancer agent in phase-2 clin. trials.
Chinese Journal of Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H5BN2O2, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts