Zhou, Jie’s team published research in Zhongguo Xinyao Zazhi in 24 | CAS: 58551-69-2

Zhongguo Xinyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H6BNO2, Quality Control of 58551-69-2.

Zhou, Jie published the artcileSimultaneous determination of the main components in carboprost tromethamine injection by HPLC-UV-CAD, Quality Control of 58551-69-2, the publication is Zhongguo Xinyao Zazhi (2015), 24(1), 22-26, 51, database is CAplus.

Objective: To establish an HPLC-UV-CAD method for the simultaneous determination of carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection. Methods: Carboprost, tromethamine and benzyl alc. were separated on a CAPCELL PAK CR 1:4 column (150 mm×4.6 mm, 5 μm). The mobile phase was composed of ultrapure water, 0.1 mol·L-1 ammonium acetate buffer (pH 6.2) and methanol with gradient elution mode at a flow about 1.0 mL·min-1; the injection volume was 10 μL and column temperature was 40 °C. CAD was used to detect carboprost and tromethamine, in which nebulization temperature was 35 °C and collection frequency was 30 Hz. UV was used to detect benzyl alc., in which detection wavelength was set at 258 nm and collection frequency was 5 Hz. Results: The linear range of carboprost was 9.38-56.2 μg·mL-1 (r = 0.997 1, n = 6); the lowest limit of detection was 0.3 μg·mL-1; LOQ was 0.6 μg·mL-1; average recovery was 104.7%. The linear range of tromethamine was 5.19-23.3 μg·mL-1 (r = 0.999 2, n = 6); the lowest limit of detection was 1 μg·mL-1; LOQ was 2.5 μg·mL-1; average recovery was 95.5%. The linear range of benzyl alc. was 0.297-1.78 mg·mL-1 (r = 1, n = 6), the lowest limit of detection was 5.0 μg·mL-1; LOQ was 10.0 μg·mL-1; average recovery was 100.1%. The actual measurement results of the sample were consistent with the standard method currently used. Conclusion: The HPLC method established does not require derivative operations, and is cheap, sensitive, simple, accurate, reproducible and accurate. This method can simultaneously detect carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection.

Zhongguo Xinyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H6BNO2, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts