Wang, Xi-Zhao’s team published research in Journal of the Chinese Chemical Society (Taipei, Taiwan) in 54 | CAS: 438565-33-4

Wang, Xi-Zhao published the artcileConcise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins, Computed Properties of 438565-33-4, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2007), 54(3), 643-652, database is CAplus.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C₆H₄-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO₂, -4-NO₂, -3-CF₃, -4-CF₃, C₆H₃-2,4-Cl₂, -3,4-Cl₂, C₆H₂-2,4,5-Cl₃, -3,4,5-Cl₃, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH₂OH using CuSO₄.5H₂O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

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