Barfoot, Katie Louise published the artcileEffects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study, Formula: C8H8O3, the publication is European Journal of Nutrition (2021), 60(8), 4263-4278, database is CAplus and MEDLINE.
Acute intervention with wild blueberry (WBB) has previously revealed pos. cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7-10-yr-old children across a 4 wk daily WBB drink intervention. This pilot study examined the effects of daily WBB consumption for 4 wk (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7-10-yr-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 wk intervention. Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 wk intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the childs version of the pos. and neg. affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 wk consumption. The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 wk daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data.
European Journal of Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.
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