Watanabe, Bunta’s team published research in Bioorganic & Medicinal Chemistry Letters in 25 | CAS: 20880-92-6

Watanabe, Bunta published the artcileSynthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors, SDS of cas: 20880-92-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(18), 3910-3913, database is CAplus and MEDLINE.

Fructosyl peptide oxidases (FPOXs) play a crucial role in the diagnosis of diabetes. Their main function is to cleave fructosyl amino acids or fructosyl peptides into glucosone and the corresponding amino acids/dipeptides. In this study, the substrate-analog FPOX inhibitors were successfully designed and synthesized. These glycosyl-amino acid inhibitors mimic N^α-fructosyl-L-valine (Fru-Val), [N^α-fructosyl-L-valyl]-L-histidine (Fru-ValHis), and N^ε-fructosyl-L-lysine (εFru-Lys), resp. The secondary nitrogen atom in the natural substrates, linking fructose and amino acid or dipeptide moieties, was substituted in glycosyl-amino acids with a sulfur atom to avoid enzymic cleavage. Kinetic studies revealed that prepared glycosyl-amino acids act as competitive inhibitors against an FPOX obtained from Coniochaeta sp., and K_i values of 11.1, 66.8, and 782 μM were obtained.

Bioorganic & Medicinal Chemistry Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15BF2O2, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts