Schoch, Silvia published the artcileTethering Carbohydrates to the Vinyliminium Ligand of Antiproliferative Organometallic Diiron Complexes, Computed Properties of 20880-92-6, the publication is Organometallics (2022), 41(5), 514-526, database is CAplus and MEDLINE.
Four propargyl O-glycosides derivatized with mannose, glucose, and fructose moieties were synthesized and then incorporated within a diiron structure as part of a vinyliminium ligand. Hence, six glycoconjugated diiron complexes, [2–5]CF3SO3 (see Scheme 1) and the nonglycosylated analogs [6a–b]CF3SO3, were obtained in high yields and unambiguously characterized by elemental anal., mass spectrometry, and IR and multinuclear NMR spectroscopies. All compounds exhibited a significant stability in DMSO-d6/D2O solution, with 63-89% of the complexes unaltered after 72 h at 37° and also in the cell culture medium. The cytotoxicity of [2–6]CF3SO3, as well as that of previously reported 7 and 8, was assessed on CT26 (mouse colon carcinoma), U87 (human glioblastoma), MCF-7 (human breast adenocarcinoma), and RPE-1 (human normal retina pigmented epithelium) cell lines. In general, the IC50 values correlate with the hydrophobicity of the compounds (measured as octanol-H2O partition coefficients) and do not show an appreciable level of selectivity against cancer cells with respect to the nontumor ones.
Organometallics published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.
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