Li, Na published the artcileDesign, synthesis and preliminary evaluation of novel imperatorin derivatives as vasorelaxant agents, SDS of cas: 101-98-4, the publication is Medicinal Chemistry (2011), 7(1), 18-23, database is CAplus and MEDLINE.
A series of novel imperatorin derivatives (I) were synthesized from com. available xanthotoxin. The in vitro pharmacol. evaluation indicated that all of the compounds possessed potent vasodilatory activity. Among them, compounds (5b) (I, R = allyl), (5d) (I, R = -CH2CH2piperidinyl) and (5e) (I, R = -CH2CH2azepanyl) exhibited higher vasodilatory activity (with EC50 values of 0.68 μM, 0.59 μM and 0.49 μM, resp.) than imperatorin (EC50 = 1.12 μM). The program Volsurf was used to predict the derivatives’ ADME-relevant descriptors. The results suggested that these novel compounds had a potential interest for the development of novel and potent vasorelaxant agents.
Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, SDS of cas: 101-98-4.
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