In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 42142-52-9 as follows., 42142-52-9
To a solution of 25 g N-methyl-3-phenyl-3-hydroxyphenyl propylamine in hexamethylphosphorous triamide and 19 g potassium f-butoxide at 50-600C was charged 50 g of 2-flourotoluene and the mixture was heated to 105-1100C. The reaction was maintained for 19-20 hours. After the completion of the reaction (monitored by TLC) there were charged 250 ml of water followed by 250 ml toluene and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with (2*75 ml) toluene. The combined organic layer was washed with (3×75 ml) water and then subjected to distillation to obtain a thick residue. The residue was dissolved in 150 ml of acetone followed by adding of 12.5 g oxalic acid and 200 ml of isopropyl ether and the mixture was stirred for 1-1.5 hours at 0-50C, then the obtained solid was separated by filtration and washed with isopropyl ether (100 ml) resulting in the (+/-)-atomoxetine oxalate with yield 62.4% and a purity of 95.4 area-% by HPLC.
The chemical industry reduces the impact on the environment during synthesis 42142-52-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/37055; (2006); A1;,
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