Ding, Feiqing published the artcileSquaryl group modified phosphoglycolipid analogs as potential modulators of GPR55, Safety of (R)-Oxiran-2-ylmethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(61), 8470-8473, database is CAplus and MEDLINE.
Lysophosphatidyl glucoside (LPGlc) is a structurally unique glycolipid that acts as a guidance cue for extending axons during central nervous system development by activating the class A G protein coupled receptor (GPR) 55 of spinal cord sensory axons. GPR55 not only plays an important role during development, but is also implicated in many disease states, rendering mols. that target GPR55 of widespread interest. In this study, we developed synthetic access to a novel class of LPGlc analogs featuring a squaryl diamide group as surrogate for the phosphodiester. We report the facile synthesis of a series of LPGlc analogs, their GPR dependent biol. activity and a systematic anal. of the structure-activity relationship in regards to GPR55 modulation. The lead compound featuring identical configuration at all stereo-centers compared to natural LPGlc exhibits an activity to repel axons of dorsal root ganglion (DGR) nociceptive neurons.
Chemical Communications (Cambridge, United Kingdom) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Safety of (R)-Oxiran-2-ylmethanol.
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