Sircar, Ila published the artcileCalcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyridinecarboxylate and analogs. Synthesis and structure-activity relationships, Formula: C10H15NO, the publication is Journal of Medicinal Chemistry (1991), 34(7), 2248-60, database is CAplus and MEDLINE.
A series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogs, e.g., I, were prepared via a three component Hantzsch reaction using a substituted benzaldehyde, enamine, and the requisite β-keto ester. These compounds possess unique profile, namely calcium channel blocking and pos. inotropic activities in vitro. Compound I was selected as the best compound in the series and was studied in detail. The synthesis and biol. profiles of enantiomers of I are also reported. The data indicate that although the calcium channel blocking property of I is stereospecific the pos. inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.
Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H6BrF3S, Formula: C10H15NO.
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