Beliaev, Alexandre published the artcileSynthesis and structure-activity relationships of ionizable 1,3,4-oxadiazol-2(3H)-ones as peripherally selective FAAH inhibitors with improved aqueous solubility, Product Details of C10H15NO, the publication is Pure and Applied Chemistry (2016), 88(4), 341-347, database is CAplus.
Novel 5-(2,4-difluorophenoxy)-3-aryl-1,3,4-oxadiazol-2(3H)-ones were prepared and in vivo SAR were discussed. Ionizable substituents on the N-Ph ring provided compounds with significantly improved aqueous solubility In addition, these analogs retained equivalent or improved potency against FAAH enzyme compared to the parent phenols. FAAH inhibition by the 2-(piperazin-1-yl)ethyl and 3-(piperazin-1-yl)propyl derivatives was confined to the periphery in mice (30 mg/kg), whereas hepatic FAAH activity was inhibited by over 90%.
Pure and Applied Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Product Details of C10H15NO.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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