Cortinas de Nava, C. published the artcileMutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system, Product Details of C28H29NO4, the publication is Mutation Research, Genetic Toxicology Testing (1983), 117(1-2), 79-91, database is CAplus and MEDLINE.
Amebicides (chloroquine (I) [54-05-7], diiodohydroxyquin [83-73-8], iodochlorohydroxyquin [130-26-7] and dehydroemetine [4914-30-1]) and anthelmintics (bephenium hydroxynaphthoate [3818-50-6], 4-hexylresorcinol [136-77-6], mebendazole [31431-39-7], niclosamide [50-65-7], pyrantel pamoate [22204-24-6] and pyrvinium pamoate [3546-41-6]) were tested for mutagenicity in the S. typhimurium microsomal test system. Frameshift mutations were induced by dehydroemetine and niclosamide following activation by microsomal enzymes, while pyrvinium pamoate induced both frameshift and base-pair substitution mutations with or without metabolic activation. The urine of mice treated with dehydroemetine or pyrvinium pamoate showed no mutagenic activity. However, urine obtained from mice treated with niclosamide was mutagenic in strains TA98 and TA1538. The fluctuation assay showed I to be mutagenic in TA1537, a strain which detects frameshift mutations.
Mutation Research, Genetic Toxicology Testing published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Product Details of C28H29NO4.
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