Rosen, G. M. published the artcileNeuromuscular blocking activity of a series of β-haloethylamines, Synthetic Route of 101-98-4, the publication is Archives Internationales de Pharmacodynamie et de Therapie (1973), 204(2), 242-51, database is CAplus and MEDLINE.
The degree of irreversible neuromuscular blockade caused by 6 β-haloethylamines that exist in equilibrium between the linear from RNMeCH2CH2Cl and the aziridinium chloride form I, depends on the stability of the aziridinium ion. Thus when the aziridinium ion is either conjugated with the aromatic ring, such as in 2-chloroethylmethylphenylamine [1669-85-8], or separated from it by methylene groups to minimize interaction with the aromatic/ring the compounds act as reversible blocking agents. Irreversible blockade is produced by compounds, such as benzyl(2-chloroethyl)methoxyethylamine [50283-06-2] in which the aziridinium ion is stabilized by interaction with the non-bonding electrons, the ether O, or with the π-electrons of the aromatic ring.
Archives Internationales de Pharmacodynamie et de Therapie published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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