Ge, Jie published the artcileEffect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects, SDS of cas: 328-90-5, the publication is International Journal of Clinical Pharmacology and Therapeutics (2015), 53(3), 272-276, database is CAplus and MEDLINE.
Objective: The objective of this study was to evaluate the pharmacokinetic parameters of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), following a single oral dose of 900 mg in healthy subjects under fed and fasting conditions. Methods: The study participants (n = 12) were randomized to receive one 900 mg triflusal capsule in a fasting condition (no food for 12 h) or a fed condition (after a high-fat meal); after a 2-wk washout period, participants received the same dose of triflusal capsule under the converse condition. Pharmacokinetic parameters were calculated using WinNonlin 6.2 software. Safety was evaluated through assessment of adverse events, standard laboratory evaluations, vital signs, and 12-lead electrocardiog. Results: The mean Cmax of triflusal and HTB were 13.96, 110.2 ug/mL for the fasting state and 9.546, 97.15 ug/mL for the fed state, resp. The AUC0-144 of triflusal and HTB were 19.66, 5,572 h × μg/mL for the fasting state and 22.20, 5,038 h × μg/mL for the fed state, the AUC0-∞ of triflusal and HTB were 19.79, 6,333 h × μg/mL for the fasting state and 22.44, 5,632 h × μg/mL for the fed state, resp. The results showed that Cmax and AUCs for triflusal were outside the bioequivalency (BE) interval after food intake, but there was no statistically significant change for HTB. Conclusion: High-fat food intake may affect the pharmacokinetics of triflusal capsule in healthy subjects.
International Journal of Clinical Pharmacology and Therapeutics published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.
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