Goulart, Cristiano O. L. published the artcileAnalysis of diglycolic acid after mass poisoning by diethylene glycol, Computed Properties of 110-99-6, the main research area is diethylene glycol diglycolic acid mass poisoning analysis.
In Dec. 2019, unusual cases of acute renal failure with neurol. changes were observed in the State of Minas Gerais, Brazil. Criminal investigations indicated cases of intoxication after consumption of beers contaminated with diethylene glycol (DEG). The elimination of DEG by the body is fast, but its metabolite, diglycolic acid (DA), may persist for a long time. To assess the level of intoxicated victims who consumed the contaminated beers, qual. and quant. methods were developed to determine DA in biol. matrixes by gas chromatog. coupled to a mass spectrometer (GC-MS) and gas chromatog. coupled to a mass spectrometer with triple-quadrupole mass filter (GC-MS-MS), resp. The validated qual. method presents good selectivity and limit of detection of 1 μg/mL (whole blood, urine, vitreous humor and cerebrospinal fluid) and 5 μg/g (liver and kidney), resp. A quant. method for whole blood presented satisfactory performance to determine DA. Twelve victims presented pos. results for DA in whole blood, with concentrations ranging from 2 to 108 μg/mL. The toxicol. laboratory of the Institute of Forensic Medicine of Minas Gerais was the first governmental agency to identify DA in whole blood, vitreous humor, cerebrospinal fluid, kidney and urine in victims affected by this contaminant. The results of this study legally supported the prohibition of the continued consumption of the beer and avoided further intoxications. Our results showed, for real cases of human intoxication, that DA can still be detected in alternative matrixes, even when non-detectable in blood, demonstrating the importance of collecting different kinds of samples for a proper investigation.
Journal of Analytical Toxicology published new progress about Beer. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Computed Properties of 110-99-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts