Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 623-50-7, Name is Ethyl 2-hydroxyacetate, molecular formula is , belongs to alcohols-buliding-blocks compound. In a document, author is Abasalta, Mahdi, Category: alcohols-buliding-blocks.
Fabrication of carboxymethyl chitosan/poly(epsilon-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer
The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(epsilon-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5-2.5 kV/cm), CMC concentration (4-6 wt.%) and PCL concentration (8-12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis. The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 623-50-7, in my other articles. Category: alcohols-buliding-blocks.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts