Wu, Dongdong published the artcilePolymers with controlled assembly and rigidity made with click-functional peptide bundles, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is polymer rigidity peptide bundle.
The engineering of biol. mols. is a key concept in the design of highly functional, sophisticated soft materials. Biomols. exhibit a wide range of functions and structures, including chem. recognition (of enzyme substrates or adhesive ligands1, for instance), exquisite nanostructures (composed of peptides2, proteins3 or nucleic acids4), and unusual mech. properties (such as silk-like strength3, stiffness5, viscoelasticity6 and resiliency7). Here the authors combine the computational design of phys. (noncovalent) interactions with pathway-dependent, hierarchical ′click′ covalent assembly to produce hybrid synthetic peptide-based polymers. The nanometer-scale monomeric units of these polymers are homotetrameric, α-helical bundles of low-mol.-weight peptides. These bundled monomers, or ′bundlemers′, can be designed to provide complete control of the stability, size and spatial display of chem. functionalities. The protein-like structure of the bundle allows precise positioning of covalent linkages between the ends of distinct bundlemers, resulting in polymers with interesting and controllable phys. characteristics, such as rigid rods, semiflexible or kinked chains, and thermally responsive hydrogel networks. Chain stiffness can be controlled by varying only the linkage. Furthermore, by controlling the amino acid sequence along the bundlemer periphery, the authors use specific amino acid side chains, including non-natural ′click′ chem. functionalities, to conjugate moieties into a desired pattern, enabling the creation of a wide variety of hybrid nanomaterials.
Nature (London, United Kingdom) published new progress about Hydrogels. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).
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