Hou, Jingang published the artcileD-galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence, HPLC of Formula: 59-23-4, the main research area is glioblastoma astrocytoma astrocyte aging progression D galactose anticancer resistance.
In the present study, we aimed to investigate the involvement of astrocytes in D-galactose-induced brain aging in vitro. We found that D-galactose treatment significantly suppressed cell viability and induced cellular senescence. in addition, as of the accumulation of senescent cells, we proposed that the senescence-associated secretory phenotype (SaSP) can stimulate age-related pathologies and chemoresistance in brain. consistently, senescent astrocytic CRT cells induced by D-galactose exhibited increases in the levels of IL-6 and IL-8 via NF-kB activation, which are major SaSP components and inflammatory cytokines. conditioned medium prepared from senescent astrocytic CRT cells significantly promoted the viability of brain tumor cells (u373-MG and n2a). importantly, conditioned medium greatly suppressed the cytotoxicity of u373-MG cells induced by temozolomide, and reduced the protein expression levels of neuron marker neuron-specific class III beta-tubulin, but markedly increased the levels of c-Myc in N2a cells. Thus, our findings demonstrated that D-galactose treatment might mimic brain aging, and that D-galactose could contribute to brain inflammation and tumor progression through inducing the accumulation of senescent-secretory astrocytes.
Molecular Medicine Reports published new progress about Apoptosis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts