Chinuki, Yuko published the artcileAlpha-Gal-containing biologics and anaphylaxis, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is review; Anaphylaxis; Cetuximab; Galactose-α-1, 3-galactose; Red meat allergy; Tick bites.
Cetuximab, the IgG1 subclass chimeric mouse-human monoclonal antibody biol. that targets the epidermal growth factor receptor (EGFR), is used worldwide for the treatment of EGFR-pos. unresectable progressive/recurrent colorectal cancer and head and neck cancer. Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti oligosaccharide IgE antibodies specific for galactose-α-1,3-galactose (α-Gal) oligosaccharide present on the mouse-derived Fab portion of the cetuximab heavy chain. Furthermore, it has been revealed that patients who are allergic to cetuximab also develop an allergic reaction to mammalian meat containing the same α-Gal oligosaccharide owing to cross-reactivity, and the presumed cause of sensitization is tick bites: Amblyomma in the United States. Investigations of cetuximab-related anaphylaxis have revealed three novel findings that improve our understanding of immediate-type allergy: 1. oligosaccharide can serve as the main IgE epitope of anaphylaxis; 2. because of the oligosaccharide epitope, a wide range of cross-reactivity with mammalian meats containing α-Gal similar to cetuximab occurs; and 3. tick bites are a crucial factor of sensitization to the oligosaccharide.
Allergology International published new progress about Amblyomma. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts