Wang, Xianheng published the artcilePreparation of Dolutegravir Intermediate Diastereomer, Safety of 2,2-Dimethoxyethanamine, the main research area is dolutegravir tricyclic intermediate diastereoselective preparation.
A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient.
Journal of Heterocyclic Chemistry published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.
Referemce:
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Alcohols – Chemistry LibreTexts