Bo, Surina published the artcileCharacterizations and immunostimulatory activities of a polysaccharide from Arnebia euchroma (Royle) Johnst. roots, Related Products of alcohols-buliding-blocks, the main research area is Arnebia BT lymphocyte root polysaccharide immunostimulatory activity; Arnebia euchroma (Royle) Johnst. polysaccharide; Immunomodulatory activities; Primary structure.
A polysaccharide from Arnebia euchroma (Royle) Johnst. named ARP, was obtained and purified by the hot water extraction, ethanol precipitation and deproteinization of TCA. The mol. weight of the polysaccharide fraction of ARP was calculated to be 1.23 × 104 Da from a calibration curve obtained with dextran standards Monosaccharide composition anal. revealed that ARP was composed of Gal, Ara, Glu, Man, Rha and Fuc at a molar ratio of 53.8:21.3:11.7:6.8:4.3:2.2. Methylation anal. suggested that ARP was likely an arabinogalactan and that its backbone mainly consisted of Galp residues of 1,6-linkages and Ara residues of 1,5- or 1,3-linkages. The in vitro experiment indicated that ARP enhanced B- and T-lymphocyte proliferation. A dose-dependent relationship was observed, and a dose of 200 mug/mL resulted in the highest cell viability. In addition, ARP significantly stimulated the production of the cytokine, interferon-gamma (IFN-G), and enhanced B- and T-lymphocyte proliferation. Meanwhile, ARP had little effect on interleukin-2 (IL-2) production The experiments of the effect of ARP on the activation of macrophage in vitro indicated that ARP significantly enhanced the production of TNF-a, IL-6 and IL-1beta which suggested the polysaccharide induced the functional activation of macrophage.
International Journal of Biological Macromolecules published new progress about Acetylation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.
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