Tabarsa, Mehdi published the artcileIsolation, structural elucidation and immuno-stimulatory properties of polysaccharides from Cuminum cyminum, HPLC of Formula: 59-23-4, the main research area is Cuminum polysaccharide structure mol weight immunostimulation signaling cytokine; Immuno-stimulatory effect; Molecular weight; Polysaccharides; Signaling pathways; Structure.
The aim of the present study was to evaluate the effect of water-soluble polysaccharides from Cuminum cyminum to induce inflammatory response in immune cells and understand their underlying mechanisms. Weight average mol. weight (Mw) of polysaccharides varied between 191.4-512.2 à 103 g/mol. Polysaccharides induced RAW264.7 cells to release nitric oxide and express TNF-α, IL-1β, IL-6 and IL-12 inflammatory cytokines. Polysaccharides activated NK-92 cells to produce TNF-α, IFN-γ, perforin, granzyme B, NKG2D and FasL. Activations of RAW264.7 and NK-92 cells were through NF-κB and MAPKs signal pathways indicated by the presence of phosphorylated NF-κB, ERK, JNK and p38 proteins. The polysaccharide structure was mainly constituted of â?)-Galp-(1â? â?)-Galp-(1â? â?)-Arap-(1â?and â?)-Arap-(1â?glycosidic linkages. Overall results suggested that polysaccharides from C. cyminum possessing lower MW and greater expanded conformation more effectively stimulate RAW264.7 and NK-92 cells and thus could be considered for further studies on their biomedical applications.
Carbohydrate Polymers published new progress about Conformation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.
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