Li, Yimeng published the artcileStructural characterization, antiproliferative and immunoregulatory activities of a polysaccharide from Boletus Leccinum rugosiceps, Computed Properties of 59-23-4, the main research area is Leccinum breast carcinoma LRP1 antiproliferative immunoregulatory activity hepatoma cell; Antitumor; Immunomodulatory; Leccinum rugosiceps; Polysaccharide; Structure.
A homogeneous water-soluble flaky polysaccharide named LRP-1 (18.82 kDa) was extracted and purified from the rare edible and medicinal fungi Leccinum rugosiceps. The structure characterization of LRP-1 was analyzed by GPC, GC, GC-MS, FT-IR, SEM, 1D/2D NMR, and its antitumor and immunoregulatory activities were determined The results show that LRP-1 is a new polysaccharide with a backbone which is mainly composed of â?-α-D-Fucp-3â? â?-α-D-Rhap-3â? â?-β-D-Glcp-6â? â?-β-D-Glcp-3â? â?-α-D-Glcp-4â? â?-β-D-Galp-6 â?and â?-α-D-Manp-6â? Results of MTT assay show that LRP-1 inhibit the growth of human hepatoma cells HepG-2 and human breast carcinoma MCF-7 cells in vitro. LRP-1 could also induce the secretion of NO and immune factors (IL-6 and TNF-α) of RAW264.7. This study suggests that LRP-1 has potential to be used as nutraceutical food with antitumor and immunoregulatory activities.
International Journal of Biological Macromolecules published new progress about Autoxidation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.
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