Wang, Ping-Ping published the artcileThe chemical structure and biological activities of a novel polysaccharide obtained from Fructus Mori and its zinc derivative, HPLC of Formula: 59-23-4, the main research area is Morus hepatoma insulinoma zinc polysaccharide MFP4P.
A novel polysaccharide (MFP4P) was isolated from mulberry fruits (Morus alba L.) pulp using a combination of DEAE-Sepharose fast-flow and Sephadex G-100 chromatog. columns. Structural characterization revealed that MFP4P was composed of arabinose, rhamnose, galactose, glucose and galacturonic acid with a mol. weight of 198.2 kDa. The linkage types of MFP4P were proved to be (1 â?6)-linked α-D-Glc, (1 â?2)-linked α-L-Rha, (1 â?3)-linked α-D-Gal, (1 â?3)-linked β-L-Rha and (1 â?)-linked α-L-Ara. The MFP4P showed good antioxidant activity with an oxygen radical absorbance capacity value of 121.8 ± 16.5 μM trolox equivalent/g. In addition, the MFP4P promoted pancreatic cell proliferation, increased insulin secretion, and enhanced glucose consumption. In the non-toxic range, the polysaccharide and zinc complexes (MFP4P-Zn) exhibited higher antioxidant and hypoglycemic activities than MFP4P at the same concentration In vivo hypoglycemic study, MFP4P and MFP4P-Zn both showed decreased blood glucose level and glucose tolerance compared with the model control group.
Journal of Functional Foods published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.
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