Chen, Ruizhan published the artcileUltrasonic disruption extraction, characterization and bioactivities of polysaccharides from wild Armillaria mellea, Formula: C6H12O6, the main research area is Armillaria polysaccharide splenocyte lymphocyte macrophage ultrasonic disruption extraction; Armillariamellea polysaccharides; Biological activities; Carbohydrate chemistry; Physicochemical properties.
An efficient ultrasonic disruption extraction (UDE) of polysaccharides from Armillariamellea (AM) were optimized by response surface methodol. (RSM). Under optimum conditions: ultrasonic power 915.00 W, temperature 69.27°C and time 39.13 min, the crude polysaccharides (AMPs) yield was 19.5%. Two purified fractions AMPs-1-1 and AMPs-2-1 were obtained through anion-exchange and gel chromatog. AMPs-1-1 was a heteropolysaccharide with average mol. weights of 1.23 × 105 Da, and composed of Glc, Gal and GlcA with mole percentages of 89.06%, 9.59% and 1.34%, resp., owning a backbone structure of (1→)-β-D-Glcp, (1 → 3,6)-α-D-Glcp and (1 → 3)-β-D-Glcp residues. AMPs-2-1 was a heteropolysaccharide with average mol. weights of 6.76 × 104 Da, and composed of Glc, Gal, GlcA and Man with mole percentages of 65.28%, 22.87%, 2.87% and 8.98%, containing a main backbone chain of (1 → 3,6)-α-D-Glcp and (1 → 6)-β-D-Glcp residues. AMPs-2-1 possessed obviously antioxidant activities in terms of stronger scavenging activity against DPPH· and ABTS+·, higher FRAP and ORAC value than AMPs-1-1. AMPs-2-1 could promote splenocyte lymphocytes and RAW264.7 macrophages proliferation and enhanced the phagocytosis of macrophages, exhibited significant immunomodulatory activities. These results suggested that UDE is an effective extract technol., and AMPs-2-1 could be explored as potential natural antioxidants and immunomodulatory agents.
International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.
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