Shaha, Rajib K. published the artcileBiocompatible liquid-crystal elastomers mimic the intervertebral disc, Quality Control of 7575-23-7, the main research area is liquid crystalline elastomer tension compression biocompatibility intervertebral disk implant; Annulus fibrosus; Biocompatibility; Biomaterial; Intervertebral disc implant; Liquid crystal elastomer; Nucleus pulposus; Porous LCE; Wettability.
The hierarchical and anisotropic mech. behavior requirement of load-bearing soft tissues limits the utility of conventional elastomeric materials as a replacement for soft-tissue materials. Liquid-crystal elastomers (LCEs) have the potential to excel in this regard owing to its unique combination of mesogenic order in an elastomeric network. In this study, the mech. behavior of the LCEs relevant to load-bearing biomedical applications was explored. LCEs with different network orientations (i.e., mesogen alignments) were investigated by fabricating the LCEs with polydomain and monodomain configurations. The polydomain and monodomain LCEs with the same degree of network crosslinking demonstrated diverse mech. behavior, ranging from highly stiff and elastic nature to high damping capacity, depending on the loading direction with respect to the network alignment. The LCEs were also capable of matching the anisotropic mech. behavior of an intervertebral disk. Addnl. studies were conducted on the in vivo biol. response of LCEs upon s.c. implantation, as well as on the effect of the exposure to an in vitro simulated physiol. environment on the mech. behavior. The LCEs mech. response was negligibly affected when exposed to biomedically relevant conditions. Furthermore, the solid and porous LCEs did not show any adverse effect on the surrounding tissues when implanted s.c. in rats. The biol. response allows for tissue ingrowth and helps illustrate their utility in implantable biol. devices. Finally, the utility of LCEs to mimic the mech. function of biol. tissue such as intervertebral disk was demonstrated by fabricating a proof of concept total disk replacement device.
Journal of the Mechanical Behavior of Biomedical Materials published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.
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