Oliveira, Ruberney S. published the artcileStructure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is fucomannogalactan mushroom Hypsizygus structure antitumor; Antimelanoma; B16-F10 cell; Chemical structure; Fucomannogalactan; Hypsizygus marmoreus; Mushroom.
A fucomannogalactan (FMG-Hm), with a mol. weight of 17.1 kDa, obtained from fruiting bodies of Hypsizygus marmoreus exhibited promising in vitro antimelanoma effects. FMG-Hm was not cytotoxic, nor did it alter the cell morphol. and proliferation, but was able to inhibit colony-forming ability and cell migration in B16-F10 murine melanoma cells. An anal. of the monosaccharide composition indicated that FMG-Hm was composed of fucose, mannose, and galactose in a ratio of 1.00:1.08:3.17. The FMG-Hm was structurally characterized based on methylation anal., partial acid hydrolysis, and NMR experiments The results indicated that FMG-Hm contained a α-(1→6)-linked galactopyranosyl main chain, partially substituted at O-2 by non-reducing ends of α-L-fucopyranose and β-D-mannopyranose. The predicted structure of the heteropolysaccharide was established.
Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
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