Hisama, Masayoshi published the artcileSuppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test, Computed Properties of 42822-86-6, the main research area is antimutagen phytoncide solution SOS response Salmonella umu gene.
Four types of phytoncide solution (A-Type, AB-Type, D-Type and G-Type) were evaluated as anti-mutagenic agents with suppressive effects on the SOS-inducing activity of the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (furylfuramide) using Salmonella typhimurium TA1535/pSK1002 umu test. The A-Type, AB-Type, D-Type and G-Type of phytoncide solution suppressed the SOS-inducing activity on furylfuramide at a concentration of 100 μg/mL by 86.1%, 74.7%, 69.5% and 55.4%, resp., and the ID50 (50% ID) values were 9.0 μg/mL, 22.5 μg/mL, 36.0 μg/mL and 72.8 μg/mL. They also showed the suppression of SOS-inducing activity against other chem. mutagens, such as 4-nitroquinoline 1-oxide (4NQO) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), which do not require liver metabolizing enzymes, and against 2-aminoanthracene (2AA) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require these enzymes, and against UV irradiation, which is a well known phys. mutagen. In the search for the component-activity relationship, the A-Type of phytoncide solution suppressed the SOS-inducing activity greater than the other types of phytoncide solution for furylfuramide, 4NQO and MNNG. However, in case of 2AA and Trp-P-1, the D-Type of phytoncide solution was most effective in suppressing the SOS-inducing activity in the umu test. From these results, the four types of phytoncide solutions showed the suppressive effect of SOS-inducing activity against chem. and phys. mutagens.
Journal of Oleo Science published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Computed Properties of 42822-86-6.
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