Datta, Hemanta Kumar published the artcileStructural elucidation of a heteropolysaccharide from the wild mushroom Marasmiellus palmivorus and its immune-assisted anticancer activity, Related Products of alcohols-buliding-blocks, the main research area is Marasmiellus heteropolysaccharide structure immunity anticancer activity; Anticancer activity; Heteropolysaccharide; Immunomodulation; Macrofungi; Marasmiellus palmivorus; Structure.
The biol. activity of macrofungal polysaccharides (MFPS) depends on their structural features and is a topic of keen interest for researchers since long time. We report a water-soluble macrofungal heteropolysaccharide (MFPS1) with a molar weight of ∼145,000 g/mol, obtained through alkali extraction, of the wild mushroom, Marasmiellus palmivorus, with significant immunomodulatory properties. In cancer, after the induction of metastasis, the anticancer immune system becomes unresponsive. By studying cytokine secretion and immune phenotyping, it was observed that MFPS1 reactivated the anticancer immune surveillance system. MFPS1 executed T-cell maturation and activation via M1Φ; and also stimulated natural killer (NK) cell and B-cell population. The entire immune activation pathway corroborates its anticancer activity. The RP-HPLC anal. of hydrolyzed MFPS1 showed arabinose, glucose, galactose, and mannose as monosaccharide units. The proposed structure of repeating unit was established from methylation anal., 1D- and 2D NMR study, HR-MS and MALDI-TOF MS anal.
Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.
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