Feng, Ying-ying published the artcilePolysaccharide extracted from Atractylodes macrocephala Koidz (PAMK) induce apoptosis in transplanted H22 cells in mice, SDS of cas: 59-23-4, the main research area is Atractylodes macrocephala Koidz polysaccharide apoptosis; Antitumor activity; Atractylodes macrocephala Koidz; Characteristics; Polysaccharide.
Polysaccharide of Atractylodes macrocephala Koidz (PAMK) was extracted by alc. sedimenting ranging from 60% to 90% and purified by ultrafiltration membrane. The high-performance gel permeation chromatog. (HPGPC), Fourier-transform IR spectroscopy (FT-IR), gas chromatog. (GC) and NMR (NMR) revealed that PAMK was a 4.1KDa neutral heteropolysaccharide composed of galactose, arabinose and glucose with a-configuration (molar ratio, 1: 1.5: 5). Results of determination of chem. components suggested that PAMK contained 96.47% of polysaccharide and little protein, nucleic acid and uronic acid. Antitumor experiments in vivo could be concluded that PAMK had a significantly cytotoxic and anti-tumor effect by blocking tumor cells in S phase. And not only that, PAMK could protect immune organ efficiently, comparing with cyclophosphamide. The research provided a potential antineoplastic drug component for tumor treatment.
International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.
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