Fischer, Pauline published the artcileSynthesis and Structural Elucidation of 1,2-Disubstituted 3-Fluoropiperidines, Application of Benzyl (5-hydroxypentyl)carbamate, the main research area is disubstituted fluoropiperidine preparation diastereoselective crystal structure mol.
This work described details of the reaction between Selectfluor and a series of 1-carbonyloxy and 1-sulfonyl 2-piperidines in order to generate 3-fluoro-2-methoxypiperidines I [R = Boc, Fmoc, Ts, etc.]. Their subsequent reaction with allyltrimethylsilane, in the presence of BF3 and TiCl4 was then reported. Studies involving a combination of single-crystal X-ray crystallog. and NMR spectroscopy indicated that the allylation process was cis-selective for both carbamate and sulfonamide variants and that optimal levels of diastereoselectivity were obtained using the N-2-nitrobenzene sulfonyl group. In this manner, the synthesis of a series of 2-allyl 3-fluoro-substituted piperidines II was achieved. The conversion of both the cis and trans-N-tosyl adducts II [R = Ts] into 3-fluorinated analogs of the natural products pelletierine and coniine was subsequently detailed.
European Journal of Organic Chemistry published new progress about Crystal structure. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application of Benzyl (5-hydroxypentyl)carbamate.
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