Hao, Huili published the artcileStructural characterization and immunostimulatory activity of a novel polysaccharide from green alga Caulerpa racemosa var peltata, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Caulerpa galacturonic acid polysaccharide immunostimulant; Caulerpa racemosa var peltata; Immunostimulatory activity; Polysaccharide; Structural characteristics.
A novel water-soluble polysaccharide (named CRVP-1) was successfully obtained from Caulerpa racemosa var peltata by hot-water extraction, ethanol precipitation, and column chromatog. The structure of CRVP-1 was characterized by HPGPC, HPAEC-PAD, FT-IR, GC-MS and NMR. The structural anal. indicated that CRVP-1 possessed a sulfate content of 25.8% ± 0.7% and was a heteropolysaccharide with an average mol. weight of 29.68 kDa, and composed of mannose, galactose, glucose, galacturonic acid, and glucuronic acid with rates of 92.1%, 2.9%, 1.8%, 1.7% and 1.2%, resp., owning a backbone structure of (1-6)-linked a-D-Manp residues with (1-4)-linked a-D-Manp and (1-2)-linked a-D-Manp residues and side chain that was consisted of (1-4)-linked b-D-Galp residues. The immunostimulatory assay revealed that CRVP-1 had significant effects on the proliferation of macrophage, production of NO and secretion of cytokines (TNF-a, IL-1b and IL-6). These findings provide a scientific basis for further utilization of polysaccharides from C. racemosa var peltata.
International Journal of Biological Macromolecules published new progress about Caulerpa racemosa. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
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