Barao de Aguiar, Michelle Maria Goncalves published the artcileOral sustained release nystatin tablets for the treatment of oral candidiasis: formulation development and validation of UV spectrophotometric analytical methodology for content determination, Product Details of C12H24O11, the main research area is tablet oral candidiasis nystatin sustained release mucoadhesion; nystatin determination UV spectrophotometry.
In this study, oral sustained release mucoadhesive nystatin tablets were developed to increase nystatin contact time with the oral cavity and mask its unpleasant taste. The best formulation studied included sustained release agents and it was submitted to phys.-mech. characterization, taste assessment and clin. test in twelve patients. The UV-visible nystatin methodol. was also developed and validated in parallel as an alternative to the pharmacopoeial microbiol. dosage method. The best formulation developed in this study included sustained release agents. The efficacy of this formulation was verified through a clin. assessment, showing that this formulation is more effective (100%) than the com. oral nystatin suspension used traditionally (50%). Moreover, the UV absorption spectrophotometry method developed to validate the methodol. for nystatin content anal. for new oral tablets was shown to be specific, linear, exact and reproducible, as recommended by the ICH regulations. The oral nystatin tablets developed showed to present faster therapeutic response than the oral aqueous solution through the preliminary clin. assays. The UV absorption spectrophotometry method showed to be an attractive test for the usual routine in the pharmaceutical industry.
Drug Development and Industrial Pharmacy published new progress about Artificial saliva. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.
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