Maghsoudi, Majid published the artcileDevelopment of electrically assisted solvent bar microextraction followed by high performance liquid chromatography for the extraction and quantification of basic drugs in biological samples, SDS of cas: 111-87-5, the main research area is solvent bar microextraction high performance liquid chromatog extraction; Basic drugs; Biological sample; Electrically assisted solvent bar microextraction; Plasma; Urine.
In this study, a new extraction procedure is introduced based on elec. assisted solvent bar microextraction In the first step, the analytes are transferred from sample solution to the hollow fiber supported organic solvent. After that, with the aid of an elec. field, the analytes migrated into the aqueous extractant. The proposed approach was used to extract the three basic drugs (including lidocaine, diltiazem, and propranolol) from the plasma and urine samples. Under the optimized condition, (the supported organic solvent: 1-octanol, stirring rate: 300 rpm, pH of sample solution: 12.0, salt concentration: 2.0% (w/v), extraction time: 15 min, aqueous extractant: (30μL, 100 mM HCl), back-extraction time: 2 min, back-extraction voltage: 100 V), the proposed procedure presented wide linearities with coefficients of determination more than 0.992 over a concentration range of 5.0-1000 ng mL-1. The limit of detection was also determined in the range of 0.5 to 5.0 ng mL-1, repeatability (intra-day) was between 3.3 and 11.1% (n = 4), and reproducibility (inter-day) was between 4.3 and 14.6% (n = 4 days). It was indicated that the proposed approach could effectively extract the analytes from the plasma and urine samples, and the relative recoveries were between 90.2 and 105.6%, indicating the validity of this method.
Journal of Chromatography A published new progress about Biological samples. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts