Di Carluccio, Cristina published the artcileCharacterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22, Related Products of alcohols-buliding-blocks, the main research area is autoimmune disease B cell malignancy CD22 N glycan; N-glycans; NMR spectroscopy; Siglecs; molecular recognition; sialic acids.
CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens. Here we have characterised the dynamic recognition of complex-type N-glycans by human CD22 by means of orthogonal approaches including NMR spectroscopy, computational methods and biophys. assays. We provide new mol. insights into the binding mode of sialoglycans in complex with h-CD22, highlighting the role of the sialic acid galactose moieties in the recognition process, elucidating the conformational behavior of complex-type N-glycans bound to Siglec-2 and dissecting the formation of CD22 homo-oligomers on the B-cell surface. Our results could enable the development of addnl. therapeutics capable of modulating the activity of h-CD22 in autoimmune diseases and malignancies derived from B-cells.
ChemBioChem published new progress about Autoimmune disease. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts