Singh, Sangh Priya published the artcileSynthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy, Computed Properties of 22483-09-6, the main research area is amino oxophenylethyl dimethoxyethyl phenylpropiolamide regioselective cycloisomerization; diphenyl pyrrolopyrazinedione preparation; benzylidene phenyl diazabicyclooctenedione preparation.
A modular approach for the construction of β- and γ-lactam fused dihydropyrazinones from the readily available Ugi adducts was described. The sequential construction of rings through base-mediated cycloisomerization followed by acid-mediated cyclization yielded β-lactam fused dihydropyrazinones. However, the Ugi-derived dihydropyrazinones afforded γ-lactam fused dihydropyrazinones under base-mediated cycloisomerization. The regioselectivity in the cycloisomerization reactions was explained on the basis of ring-strain. Substrate scope, limitations and mechanistic investigations through DFT-calculations was explored.
Chemical Communications (Cambridge, United Kingdom) published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.
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