Bole, Leonie J. published the artcileUntangling the Complexity of Mixed Lithium/Magnesium Alkyl/Alkoxy Combinations Utilised in Bromine/Magnesium Exchange Reactions, Quality Control of 2212-32-0, the main research area is lithium magnesium alkyl alkoxy bromine exchange reaction reactivity substitution; crystal structure mol lithium magnesium alkyl alkoxy complex preparation; alkoxides; bromine/magnesium exchange; lithium; magnesium; mixed-aggregates.
While it is known that the addition of Group 1 alkoxides to s-block organometallics can have an activating effect on reactivity, the exact nature of this effect is not that well understood. Here we describe the activation of sBu2Mg towards substituted bromoarenes by adding one equivalent of LiOR (R = 2-ethylhexyl), where unusually both sBu groups can undergo efficient Br/Mg exchange. Depending on the substitution pattern on the bromoarene two different types of organometallic intermediates have been isolated, either a mixed aryl/alkoxide [{LiMg(2-FG-C6H4)2(OR)}2] (FG = OMe; NMe2) or a homoaryl [(THF)4Li2Mg(4-FG-C6H4)4] (FG = OMe, F). Detailed NMR spectroscopic studies have revealed that these exchange reactions and the formation of their intermediates are controlled by a new type of bimetallic Schlenk-type equilibrium between heteroleptic [LiMgsBu2(OR)], alkyl rich [Li2MgsBu4] and Mg(OR)2, with [Li2MgsBu4] being the active species performing the Br/Mg exchange process.
Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Quality Control of 2212-32-0.
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