Kurandina, Daria published the artcileTransition-Metal- and Light-Free Directed Amination of Remote Unactivated C(sp3)-H Bonds of Alcohols, Product Details of C5H12O, the main research area is directed remote amination aliphatic alc diazonium salt.
Due to the great value of amino alcs., new methods for their synthesis are in high demand. Abundant aliphatic alcs. represent the ideal feedstock for the method development toward this important motif. To date, transition-metal-catalyzed approaches for the directed remote amination of alcs. have been well established. Yet, they have certain disadvantages such as the use of expensive catalysts and limited scope. Very recently, transition-metal-free visible-light-induced radical approaches have emerged as new powerful tools for directed remote amination of alcs. Relying on 1,5-HAT reactivity, these methods are limited to β- or δ-amination only. Herein, we report a novel transition-metal- and visible-light-free room-temperature radical approach for remote β-, γ-, and δ-C(sp3)-N bond formation in aliphatic alcs. using mild basic conditions and readily available diazonium salt reagents. Thus, e.g., reaction of silylmethyl iodide I with PhN2.BF4- afforded II (76%, GC-MS yield) in presence of HCO2Li.H2O as base and reducing agent in DMA/MeOH mixed solvent.
Journal of the American Chemical Society published new progress about Abstraction reaction (iodine abstraction from silylmethyl iodide). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts