Li, Zhengnian published the artcileDiscovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing, Name: 2,2-Dimethoxyethanamine, the main research area is benzopyrimidodiazepinone TNK2 inhibitor; Benzopyrimidodiazepinone; Kinase inhibitor; Scaffold morphing; TNK2.
The protein kinase TNK2 (ACK1) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role transmitting cell survival, growth and proliferative signals via modification of multiple downstream effectors by unique tyrosine phosphorylation events. Scaffold morphing based on our previous TNK2 inhibitor XMD8-87 identified urea 17 (I) from which we developed the potent and selective compound 32 (II). A co-crystal structure was obtained showing 32 interacting primarily with the main chain atoms of an alanine residue of the hinge region. Addnl. H-bonds exist between the urea NHs and the Thr205 and Asp270 residues.
Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure (co-crystal structure of enzyme-inhibitor complex). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.
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