Zhang, Xinfu published the artcileRatiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice, Computed Properties of 2212-32-0, the main research area is ratiometric fluorescent hypochlorous acid.
Hypochlorous acid (HClO) is a promising diagnostic marker for inflammation and relevant diseases. Although many probes were previously developed for HClO imaging, the development of organ targeting probes is still lacking. Herein, we designed and synthesized a series of cyanine derivatives as ratiometric fluorescent probes to detect endogenous HClO in the lungs with inflammation. By installing diverse lipid chains and amino groups on cyanine, we identified that ClO1, with one n-octadecane chain and two 2-[[2-(dimethylamino)ethyl]methylamino]-Et groups, is a superior probe to target the lungs over other major organs in mice. ClO1 was able to sense both exogenous and endogenous HClO in A549 (human lung epithelial) cells through fluorescence ratiometric imaging. In a lipopolysaccharide (LPS)-induced lung inflammation mouse model, ClO1 effectively captured endogenous HClO in the lungs after i.v. administration. Overall, these cyanine-derived probes merit further development as organ targeting HClO sensors.
Chemical Science published new progress about Cyanines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Computed Properties of 2212-32-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts