Pungente, Michael D. published the artcileAntibody-catalyzed formation of a 14-membered ring lactone, Formula: C13H19NO3, the main research area is macrocyclic phosphonate lactone preparation monoclonal antibody catalyst.
Monoclonal antibody (MAb) F123, raised against a macrocyclic phosphonate transition-state analog, catalyzed an intramol. transesterification of the corresponding hydroxy ester to give a 14-membered ring lactone. The MAB reaction displayed enzyme-like Michaelis-Menten kinetics with a Km of 255 μM and a kcat of 0.01 min-1 based on p-nitrophenol release and calculated on an active-site basis. Substrate specificity and competitive inhibition by a transition state analog (Ki = 3 μM) demonstrated that the catalytic activity was associated with binding in the antibody-combining site. The lactone product was isolated from a large-scale catalytic experiment through ether extraction and identified by gas chromatog. – mass spectroscopy.
Canadian Journal of Chemistry published new progress about Catalytic monoclonal antibodies Role: CAT (Catalyst Use), USES (Uses) (F123). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Formula: C13H19NO3.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts